Pointer settings for large displays
A larger pointer
Open the Pointers module and choose a larger value in the Size field, if your theme offers one.
To set it by hand instead, open ~/.config/kcminputrc in a text editor. In the [Mouse] section, add this line and save the file:
cursorSize=32
The pointer is larger the next time you log in.
Better acceleration
The Mouse module has the pointer speed and acceleration settings, including Legacy X11 acceleration and Acceleration threshold. You can set a really fast acceleration there, for example 20x, and a threshold of 2 pixels.
That acceleration should be fine at medium distances but too fast over longer ones. Here's the trick to get better acceleration:
Press Alt+F2, enter konsole and press Return. In the console window, find the name of your mouse with:
xinput list
Then, in the Autostart module, add a login script containing this line, replacing Logitech USB-PS/2 Optical Mouse with the name of your mouse:
xinput --set-prop "Logitech USB-PS/2 Optical Mouse" "Device Accel Constant Deceleration" 1.2
Your mouse acceleration is better the next time you log in.